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Therapeutic Targeting of Siglecs using Antibody- and Glycan-based Approaches
The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs are attractive therapeutic targets because of their cell-type specific expression pattern, endocytic properties, high expression on...
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| Опубликовано в: : | Trends Pharmacol Sci |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593978/ https://ncbi.nlm.nih.gov/pubmed/26435210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2015.06.008 |
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