Kinetic characterization of trans-proteolytic activity of Chikungunya virus capsid protease and development of a FRET-based HTS assay

Chikungunya virus (CHIKV) capsid protein (CVCP) is a serine protease that possesses cis-proteolytic activity essential for the structural polyprotein processing and plays a key role in the virus life cycle. CHIKV being an emerging arthropod-borne pathogenic virus, is a public health concern worldwid...

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Vydáno v:Sci Rep
Hlavní autoři: Aggarwal, Megha, Sharma, Rajesh, Kumar, Pravindra, Parida, Manmohan, Tomar, Shailly
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593962/
https://ncbi.nlm.nih.gov/pubmed/26439734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14753
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