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IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3
CD4(+)FOXP3(+) regulatory T (Treg) cells are essential for maintaining immunological self-tolerance. Treg cell development and function depend on the transcription factor FOXP3, which is present in several distinct isoforms due to alternative splicing. Despite the importance of FOXP3 in the proper m...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593960/ https://ncbi.nlm.nih.gov/pubmed/26441347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14674 |
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