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IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity
Environmental signals can be translated into chromatin changes, which alter gene expression. Here we report a novel concept that cells can signal chromatin damage from the nucleus back to the surrounding tissue through the cytokine interleukin-1alpha (IL-1α). Thus, in addition to its role as a dange...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593953/ https://ncbi.nlm.nih.gov/pubmed/26439902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14756 |
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