The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells

During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to promote cell survival, and to induce pro-angiogenic factors. Hypoxia-induced factors (HIFs) regulate these transcriptional alterations. Failure to restore oxygen levels results in cell death by necrosis. IL-1α is...

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Main Authors: Rider, Peleg, Kaplanov, Irena, Romzova, Marianna, Bernardis, Liora, Braiman, Alex, Voronov, Elena, Apte, Ron N.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Research Foundation 2012
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442192/
https://ncbi.nlm.nih.gov/pubmed/23049530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2012.00290
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