Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury

Post-traumatic seizures can exacerbate injurious outcomes of severe brain trauma, yet effective treatments are limited owing to the complexity of the pathology underlying the concomitant occurrence of both events. In this study, we tested C‐10068, a novel deuterium-containing analog of (+)-N-methyl-...

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Udgivet i:J Neurotrauma
Main Authors: Lu, Xi-Chun May, Shear, Deborah A., Graham, Philip B., Bridson, Gary W., Uttamsingh, Vinita, Chen, Zhiyong, Leung, Lai Yee, Tortella, Frank C.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2015
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593875/
https://ncbi.nlm.nih.gov/pubmed/25794265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2014.3766
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