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Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury

Post-traumatic seizures can exacerbate injurious outcomes of severe brain trauma, yet effective treatments are limited owing to the complexity of the pathology underlying the concomitant occurrence of both events. In this study, we tested C‐10068, a novel deuterium-containing analog of (+)-N-methyl-...

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Detalhes bibliográficos
Publicado no:J Neurotrauma
Main Authors: Lu, Xi-Chun May, Shear, Deborah A., Graham, Philip B., Bridson, Gary W., Uttamsingh, Vinita, Chen, Zhiyong, Leung, Lai Yee, Tortella, Frank C.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593875/
https://ncbi.nlm.nih.gov/pubmed/25794265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2014.3766
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