The human parasite Leishmania amazonensis downregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway

Leishmania amazonensis activates the NF-κB transcriptional repressor homodimer (p50/p50) and promotes nitric oxide synthase (iNOS) downregulation. We investigated the role of PI3K/Akt in p50/p50 NF-κB activation and the effect on iNOS expression in L. amazonensis infection. The increased occupancy o...

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Detalles Bibliográficos
Publicado en:Open Biol
Main Authors: Calegari-Silva, Teresa C., Vivarini, Áislan C., Miqueline, Marina, Dos Santos, Guilherme R. R. M., Teixeira, Karina Luiza, Saliba, Alessandra Mattos, Nunes de Carvalho, Simone, de Carvalho, Laís, Lopes, Ulisses G.
Formato: Artigo
Idioma:Inglês
Publicado: The Royal Society 2015
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593669/
https://ncbi.nlm.nih.gov/pubmed/26400473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.150118
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