The human parasite Leishmania amazonensis downregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway

Leishmania amazonensis activates the NF-κB transcriptional repressor homodimer (p50/p50) and promotes nitric oxide synthase (iNOS) downregulation. We investigated the role of PI3K/Akt in p50/p50 NF-κB activation and the effect on iNOS expression in L. amazonensis infection. The increased occupancy o...

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Detaylı Bibliyografya
Yayımlandı:Open Biol
Asıl Yazarlar: Calegari-Silva, Teresa C., Vivarini, Áislan C., Miqueline, Marina, Dos Santos, Guilherme R. R. M., Teixeira, Karina Luiza, Saliba, Alessandra Mattos, Nunes de Carvalho, Simone, de Carvalho, Laís, Lopes, Ulisses G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Royal Society 2015
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593669/
https://ncbi.nlm.nih.gov/pubmed/26400473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.150118
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