The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits

The anthelmintic emodepside paralyses adult filarial worms, via a mode of action distinct from previous anthelmintics and has recently garnered interest as a new treatment for onchocerciasis. Whole organism data suggest its anthelmintic action is underpinned by a selective activation of the nematode...

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Détails bibliographiques
Publié dans:PLoS Negl Trop Dis
Auteurs principaux: Crisford, Anna, Ebbinghaus-Kintscher, Ulrich, Schoenhense, Eva, Harder, Achim, Raming, Klaus, O’Kelly, Ita, Ndukwe, Kelechi, O’Connor, Vincent, Walker, Robert J., Holden-Dye, Lindy
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593646/
https://ncbi.nlm.nih.gov/pubmed/26437177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004062
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