Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model

Cytokines such as TNFα can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is thought to impair phagocytosis and has been described in Alzheimer’s Disease (AD). Neuroinflammation can be perpetuated by a cycle of increasing cyt...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Gabbita, S. Prasad, Johnson, Ming F., Kobritz, Naomi, Eslami, Pirooz, Poteshkina, Aleksandra, Varadarajan, Sridhar, Turman, John, Zemlan, Frank, Harris-White, Marni E.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593589/
https://ncbi.nlm.nih.gov/pubmed/26436670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137305
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы