Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model

Cytokines such as TNFα can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is thought to impair phagocytosis and has been described in Alzheimer’s Disease (AD). Neuroinflammation can be perpetuated by a cycle of increasing cyt...

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Udgivet i:PLoS One
Main Authors: Gabbita, S. Prasad, Johnson, Ming F., Kobritz, Naomi, Eslami, Pirooz, Poteshkina, Aleksandra, Varadarajan, Sridhar, Turman, John, Zemlan, Frank, Harris-White, Marni E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593589/
https://ncbi.nlm.nih.gov/pubmed/26436670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137305
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