Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity

Advances in protein therapy are hindered by the poor stability, inadequate pharmacokinetic (PK) profiles, and immunogenicity of many therapeutic proteins. Polyethylene glycol conjugation (PEGylation) is the most successful strategy to date to overcome these shortcomings, and more than 10 PEGylated p...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhang, Peng, Sun, Fang, Tsao, Caroline, Liu, Sijun, Jain, Priyesh, Sinclair, Andrew, Hung, Hsiang-Chieh, Bai, Tao, Wu, Kan, Jiang, Shaoyi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593115/
https://ncbi.nlm.nih.gov/pubmed/26371311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512465112
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