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Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity

Advances in protein therapy are hindered by the poor stability, inadequate pharmacokinetic (PK) profiles, and immunogenicity of many therapeutic proteins. Polyethylene glycol conjugation (PEGylation) is the most successful strategy to date to overcome these shortcomings, and more than 10 PEGylated p...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Zhang, Peng, Sun, Fang, Tsao, Caroline, Liu, Sijun, Jain, Priyesh, Sinclair, Andrew, Hung, Hsiang-Chieh, Bai, Tao, Wu, Kan, Jiang, Shaoyi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2015
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593115/
https://ncbi.nlm.nih.gov/pubmed/26371311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512465112
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