Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity

Advances in protein therapy are hindered by the poor stability, inadequate pharmacokinetic (PK) profiles, and immunogenicity of many therapeutic proteins. Polyethylene glycol conjugation (PEGylation) is the most successful strategy to date to overcome these shortcomings, and more than 10 PEGylated p...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Peng, Sun, Fang, Tsao, Caroline, Liu, Sijun, Jain, Priyesh, Sinclair, Andrew, Hung, Hsiang-Chieh, Bai, Tao, Wu, Kan, Jiang, Shaoyi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593115/
https://ncbi.nlm.nih.gov/pubmed/26371311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512465112
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