Induction of TAp73 by platinum-based compounds to overcome drug resistance in p53 dysfunctional chronic lymphocytic leukemia

In chronic lymphocytic leukemia (CLL), strategies to overcome drug resistance due to p53 dysfunction are highly needed. Platinum-based compounds such as cisplatinum (CDDP) are active in fludarabine-refractory CLL through a largely unknown mechanism. We analyzed the mechanism of action of CDDP in the...

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Detalhes bibliográficos
Publicado no:Leuk Lymphoma
Main Authors: Tonino, Sanne H., Mulkens, Chantal E., van Laar, Jacoline, Derks, Ingrid A. M., Suo, Guangli, Boer, Fransien Croon-de, van Oers, Marinus H. J., Eldering, Eric, Wang, Jean Y., Kater, Arnon P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592483/
https://ncbi.nlm.nih.gov/pubmed/25511680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2014.996751
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