Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma

B-cell lymphomas frequently contain genomic rearrangements that lead to oncogene activation by heterologous distal regulatory elements. We utilized a novel approach, termed ‘Pinpointing Enhancer-Associated Rearrangements by Chromatin Immunoprecipitation’ or PEAR-ChIP, to simultaneously map enhancer...

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Détails bibliographiques
Publié dans:Cancer Discov
Auteurs principaux: Ryan, Russell J.H., Drier, Yotam, Whitton, Holly, Cotton, M. Joel, Kaur, Jasleen, Issner, Robbyn, Gillespie, Shawn, Epstein, Charles B., Nardi, Valentina, Sohani, Aliyah R., Hochberg, Ephraim P., Bernstein, Bradley E.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592453/
https://ncbi.nlm.nih.gov/pubmed/26229090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0370
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