Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma

BACKGROUND: Recent evidence suggests that progesterone metabolites play important roles in regulating breast cancer. Previous studies have shown that tumorous tissues have higher 5α-reductase (5αR) and lower 3α-hydroxysteroid oxidoreductase (3α-HSO) and 20α-HSO activities. The resulting higher level...

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Detaylı Bibliyografya
Asıl Yazarlar: Lewis, Michael J, Wiebe, John P, Heathcote, J Godfrey
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2004
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC459223/
https://ncbi.nlm.nih.gov/pubmed/15212687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-4-27
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