Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations

Interindividual variability in anatomical and physiological properties results in significant differences in drug pharmacokinetics. The consideration of such pharmacokinetic variability supports optimal drug efficacy and safety for each single individual, e.g. by identification of individual-specifi...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Krauss, Markus, Tappe, Kai, Schuppert, Andreas, Kuepfer, Lars, Goerlitz, Linus
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592188/
https://ncbi.nlm.nih.gov/pubmed/26431198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139423
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