Translational learning from clinical studies predicts drug pharmacokinetics across patient populations

Early indication of late-stage failure of novel candidate drugs could be facilitated by continuous integration, assessment, and transfer of knowledge acquired along pharmaceutical development programs. We here present a translational systems pharmacology workflow that combines drug cocktail probing...

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Detalhes bibliográficos
Publicado no:NPJ Syst Biol Appl
Main Authors: Krauss, Markus, Hofmann, Ute, Schafmayer, Clemens, Igel, Svitlana, Schlender, Jan, Mueller, Christian, Brosch, Mario, von Schoenfels, Witigo, Erhart, Wiebke, Schuppert, Andreas, Block, Michael, Schaeffeler, Elke, Boehmer, Gabriele, Goerlitz, Linus, Hoecker, Jan, Lippert, Joerg, Kerb, Reinhold, Hampe, Jochen, Kuepfer, Lars, Schwab, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460240/
https://ncbi.nlm.nih.gov/pubmed/28649438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-017-0012-5
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