The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

Many neurological and psychiatric maladies originate from the deprivation of the human brain from estrogens. However, current hormone therapies cannot be used safely to treat these conditions commonly associated with menopause because of detrimental side-effects in the periphery. The latter also pre...

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Udgivet i:Sci Transl Med
Main Authors: Prokai, Laszlo, Nguyen, Vien, Szarka, Szabolcs, Garg, Puja, Sabnis, Gauri, Bimonte-Nelson, Heather A., McLaughlin, Katie J., Talboom, Joshua S., Conrad, Cheryl D., Shughrue, Paul J., Gould, Todd D., Brodie, Angela, Merchenthaler, Istvan, Koulen, Peter, Prokai-Tatrai, Katalin
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591937/
https://ncbi.nlm.nih.gov/pubmed/26203081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aab1290
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