Cleavage and Cell Adhesion Properties of Human Epithelial Cell Adhesion Molecule (HEPCAM)

Human epithelial cell adhesion molecule (HEPCAM) is a tumor-associated antigen frequently expressed in carcinomas, which promotes proliferation after regulated intramembrane proteolysis. Here, we describe extracellular shedding of HEPCAM at two α-sites through a disintegrin and metalloprotease (ADAM...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Tsaktanis, Thanos, Kremling, Heidi, Pavšič, Miha, von Stackelberg, Ricarda, Mack, Brigitte, Fukumori, Akio, Steiner, Harald, Vielmuth, Franziska, Spindler, Volker, Huang, Zhe, Jakubowski, Jasmine, Stoecklein, Nikolas H., Luxenburger, Elke, Lauber, Kirsten, Lenarčič, Brigita, Gires, Olivier
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591836/
https://ncbi.nlm.nih.gov/pubmed/26292218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662700
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