Cyclic diGMP Regulates Production of Sortase Substrates of Clostridium difficile and Their Surface Exposure through ZmpI Protease-mediated Cleavage

In Gram-positive pathogens, surface proteins may be covalently anchored to the bacterial peptidoglycan by sortase, a cysteine transpeptidase enzyme. In contrast to other Gram-positive bacteria, only one single sortase enzyme, SrtB, is conserved between strains of Clostridium difficile. Sortase-media...

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Vydáno v:J Biol Chem
Hlavní autoři: Peltier, Johann, Shaw, Helen A., Couchman, Edward C., Dawson, Lisa F., Yu, Lu, Choudhary, Jyoti S., Kaever, Volkhard, Wren, Brendan W., Fairweather, Neil F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591827/
https://ncbi.nlm.nih.gov/pubmed/26283789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.665091
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