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Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products

Fungal polyketides are a diverse class of natural products, or secondary metabolites (SMs), with a wide range of bioactivities often associated with toxicity. Here, we focus on a group of non-reducing polyketide synthases (NR-PKSs) in the fungal phylum Ascomycota that lack a thioesterase domain for...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Throckmorton, Kurt, Wiemann, Philipp, Keller, Nancy P.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591646/
https://ncbi.nlm.nih.gov/pubmed/26378577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins7093572
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