Activation of angiotensin II type 2 receptor suppresses TNF-α-induced ICAM-1 via NF-кB: possible role of ACE2

ANG II type 2 receptor (AT(2)) and ANG I-converting enzyme 2 (ACE2) are important components of the renin-ANG system. Activation of AT(2) and ACE2 reportedly counteracts proinflammatory effects of ANG II. However, the possible interaction between AT(2) and ACE2 has never been established. We hypothe...

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Publicado en:Am J Physiol Heart Circ Physiol
Autores principales: Zhu, Liping, Carretero, Oscar A., Xu, Jiang, Harding, Pamela, Ramadurai, Nithya, Gu, Xiaosong, Peterson, Edward, Yang, Xiao-Ping
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2015
Materias:
Vascular Biology and Microcirculation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591403/
https://ncbi.nlm.nih.gov/pubmed/26163449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00814.2014
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