Heterogeneous Mechanisms of Secondary Resistance and Clonal Selection in Sarcoma during Treatment with Nutlin

Nutlin inhibits TP53-MDM2 interaction and is under investigation in soft-tissue sarcomas (STS) and other malignancies. Molecular mechanisms of secondary resistance to nutlin in STS are unknown. We performed whole-transcriptome sequencing (RNA-seq) on three pretreatment and secondary resistant STS ce...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Laroche, Audrey, Tran-Cong, Kevin, Chaire, Vanessa, Lagarde, Pauline, Hostein, Isabelle, Coindre, Jean-Michel, Chibon, Frederic, Neuville, Agnes, Lesluyes, Tom, Lucchesi, Carlo, Italiano, Antoine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591276/
https://ncbi.nlm.nih.gov/pubmed/26427052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137794
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