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Neurodegeneration in Autoimmune Optic Neuritis Is Associated with Altered APP Cleavage in Neurons and Up-Regulation of p53

Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS). Histopathological and radiological analysis revealed that neurodegeneration occurs early in the disease course. However, the pathological mechanisms involved in neurodegeneration are poorly unde...

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Publicat a:PLoS One
Autors principals: Herold, Sabine, Kumar, Prateek, Wichert, Sven P., Kretzschmar, Benedikt, Bähr, Mathias, Rossner, Moritz J., Hein, Katharina
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591258/
https://ncbi.nlm.nih.gov/pubmed/26426258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138852
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