Anti-Inflammatory Effects of FTY720 Do Not Prevent Neuronal Cell Loss in a Rat Model of Optic Neuritis

In multiple sclerosis, long-term disability is caused by axonal and neuronal damage. Established therapies target primarily the inflammatory component of the disease, but fail to prevent neurodegeneration. Fingolimod (codenamed FTY720) is an oral sphingosine 1-phosphate (S1P) receptor modulator with...

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Detalhes bibliográficos
Principais autores: Rau, Christian R., Hein, Katharina, Sättler, Muriel B., Kretzschmar, Benedikt, Hillgruber, Carina, McRae, Bradford L., Diem, Ricarda, Bähr, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078467/
https://ncbi.nlm.nih.gov/pubmed/21406175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.003
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