Diminished MTORC1-Dependent JNK-Activation Underlies Neurodevelopmental Defects Associated with Lysosomal Dysfunction

We evaluate the mechanisms underlying neurodevelopmental deficits in Drosophila and mouse models of lysosomal storage diseases (LSDs). We find that lysosomes promote the growth of neuromuscular junctions (NMJs) via Rag GTPases and Mechanistic Target of Rapamycin Complex 1 (MTORC1). However, rather t...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Wong, Ching-On, Palmieri, Michela, Li, Jiaxing, Akhmedov, Dmitry, Chao, Yufang, Broadhead, Geoffrey T., Zhu, Michael X., Berdeaux, Rebecca, Collins, Catherine A., Sardiello, Marco, Venkatachalam, Kartik
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591237/
https://ncbi.nlm.nih.gov/pubmed/26387958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.047
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