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Three-dimensional DEM–CFD analysis of air-flow-induced detachment of API particles from carrier particles in dry powder inhalers

Air flow and particle–particle/wall impacts are considered as two primary dispersion mechanisms for dry powder inhalers (DPIs). Hence, an understanding of these mechanisms is critical for the development of DPIs. In this study, a coupled DEM–CFD (discrete element method–computational fluid dynamics)...

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Veröffentlicht in:Acta Pharm Sin B
Hauptverfasser: Yang, Jiecheng, Wu, Chuan-Yu, Adams, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590728/
https://ncbi.nlm.nih.gov/pubmed/26579364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2013.11.003
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