Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration

The purpose of this study was to compare the pharmacokinetic profiles of tetramethylpyrazine phosphate (TMPP) in plasma and extracellular fluid of the cerebral cortex of rats via three delivery routes: intranasal (i.n.), intragastric (i.g.) and intravenous (i.v.) administration. After i.n., i.g. and...

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Vydáno v:Acta Pharm Sin B
Hlavní autoři: Meng, Dongmei, Lu, Haoyang, Huang, Shanshan, Wei, Minyan, Ding, Pingtian, Xiao, Xianglin, Xu, Yuehong, Wu, Chuanbin
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590719/
https://ncbi.nlm.nih.gov/pubmed/26579367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2013.12.009
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