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Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration

The purpose of this study was to compare the pharmacokinetic profiles of tetramethylpyrazine phosphate (TMPP) in plasma and extracellular fluid of the cerebral cortex of rats via three delivery routes: intranasal (i.n.), intragastric (i.g.) and intravenous (i.v.) administration. After i.n., i.g. and...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Meng, Dongmei, Lu, Haoyang, Huang, Shanshan, Wei, Minyan, Ding, Pingtian, Xiao, Xianglin, Xu, Yuehong, Wu, Chuanbin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590719/
https://ncbi.nlm.nih.gov/pubmed/26579367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2013.12.009
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