Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration

The purpose of this study was to compare the pharmacokinetic profiles of tetramethylpyrazine phosphate (TMPP) in plasma and extracellular fluid of the cerebral cortex of rats via three delivery routes: intranasal (i.n.), intragastric (i.g.) and intravenous (i.v.) administration. After i.n., i.g. and...

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Udgivet i:Acta Pharm Sin B
Main Authors: Meng, Dongmei, Lu, Haoyang, Huang, Shanshan, Wei, Minyan, Ding, Pingtian, Xiao, Xianglin, Xu, Yuehong, Wu, Chuanbin
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590719/
https://ncbi.nlm.nih.gov/pubmed/26579367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2013.12.009
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