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Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges

Drug discovery and development has become longer and costlier process. The fear of failure and stringent regulatory review process is driving pharmaceutical companies towards “me too” drugs and improved generics (505(b) (2)) fillings. The discontinuance of molecules at late stage clinical trials is...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Pharm Sin B
Prif Awduron: Basavaraj, S, Betageri, Guru V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590717/
https://ncbi.nlm.nih.gov/pubmed/26579359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2013.12.003
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