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Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges

Drug discovery and development has become longer and costlier process. The fear of failure and stringent regulatory review process is driving pharmaceutical companies towards “me too” drugs and improved generics (505(b) (2)) fillings. The discontinuance of molecules at late stage clinical trials is...

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Опубликовано в: :Acta Pharm Sin B
Главные авторы: Basavaraj, S, Betageri, Guru V.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590717/
https://ncbi.nlm.nih.gov/pubmed/26579359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2013.12.003
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