A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

Autophagy inhibition has been widely accepted as a promising therapeutic strategy in cancer, while the lack of effective and specific autophagy inhibitors hinders its application. Here we found that liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking a...

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Zhou, Jing, Li, Guobing, Zheng, Yi, Shen, Han-Ming, Hu, Xiaoye, Ming, Qian-Liang, Huang, Cheng, Li, Peng, Gao, Ning
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
Soggetti:
Basic Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590597/
https://ncbi.nlm.nih.gov/pubmed/26114658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1056970
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