Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L

PRKAA (protein kinase, AMP-activated, α catalytic subunit) regulates mitochondrial biogenesis, function, and turnover. However, the molecular mechanisms by which PRKAA regulates mitochondrial dynamics remain poorly characterized. Here, we report that PRKAA regulated mitochondrial fission via the aut...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Wang, Qilong, Wu, Shengnan, Zhu, Huaiping, Ding, Ye, Dai, Xiaoyan, Ouyang, Changhan, Han, Young-min, Xie, Zhonglin, Zou, Ming-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324848/
https://ncbi.nlm.nih.gov/pubmed/28085543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1263776
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