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Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood–brain barrier and glioma cells

Clinical applications of siRNA for treating disorders in the central nervous system require development of systemic stable, safe, and effective delivery vehicles that are able to cross the impermeable blood–brain barrier (BBB). Engineering nanocarriers with low cellular interaction during systemic c...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Bruun, Jonas, Larsen, Trine B, Jølck, Rasmus I, Eliasen, Rasmus, Holm, René, Gjetting, Torben, Andresen, Thomas L
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590347/
https://ncbi.nlm.nih.gov/pubmed/26451106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S87334
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