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Enhanced delivery of hydrophilic peptides in vitro by transdermal microneedle pretreatment

The aims of this study were to investigate the utility of solid microneedle arrays (150 µm in length) in enhancing transdermal delivery of peptides and to examine the relationship between peptide permeation rates and D(2)O flux. Four model peptides were used (Gly–Gln–Pro–Arg [tetrapeptide-3, 456.6 D...

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Pubblicato in:Acta Pharm Sin B
Autori principali: Zhang, Suohui, Qiu, Yuqin, Gao, Yunhua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590292/
https://ncbi.nlm.nih.gov/pubmed/26579370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2013.12.011
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