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Enhanced delivery of hydrophilic peptides in vitro by transdermal microneedle pretreatment

The aims of this study were to investigate the utility of solid microneedle arrays (150 µm in length) in enhancing transdermal delivery of peptides and to examine the relationship between peptide permeation rates and D(2)O flux. Four model peptides were used (Gly–Gln–Pro–Arg [tetrapeptide-3, 456.6 D...

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Библиографические подробности
Опубликовано в: :Acta Pharm Sin B
Главные авторы: Zhang, Suohui, Qiu, Yuqin, Gao, Yunhua
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590292/
https://ncbi.nlm.nih.gov/pubmed/26579370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2013.12.011
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