Mechanisms of Catalysis and Inhibition Operative in the Arginine Deiminase from the Human Pathogen Giardia lamblia()

Giardia lamblia arginine deiminase (GlAD), the topic of this paper, belongs to the hydrolase branch of the guanidine-modifying enzyme superfamily, whose members employ Cys-mediated nucleophilic catalysis to promote deimination of L-arginine and its naturally occurring derivatives. G. lamblia is the...

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Published in:Bioorg Chem
Main Authors: Li, Zhimin, Kulakova, Liudmila, Li, Ling, Galkin, Andrey, Zhao, Zhiming, Knipp, Markus, Nash, Theodore E., Mariano, Patrick S., Herzberg, Osnat, Dunaway-Mariano, Debra
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590290/
https://ncbi.nlm.nih.gov/pubmed/19640561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2009.06.001
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