Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses

DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and Sudan virus (SUDV) produce fully human polyclonal antibodies (pAbs) that recognize both viruses and demonstrate robust neutralizing activity. Eac...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bounds, Callie E., Kwilas, Steven A., Kuehne, Ana I., Brannan, Jennifer M., Bakken, Russell R., Dye, John M., Hooper, Jay W., Dupuy, Lesley C., Ellefsen, Barry, Hannaman, Drew, Wu, Hua, Jiao, Jin-an, Sullivan, Eddie J., Schmaljohn, Connie S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589376/
https://ncbi.nlm.nih.gov/pubmed/26422247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137786
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados