Endocytosed β2-Microglobulin Amyloid Fibrils Induce Necrosis and Apoptosis of Rabbit Synovial Fibroblasts by Disrupting Endosomal/Lysosomal Membranes: A Novel Mechanism on the Cytotoxicity of Amyloid Fibrils

Dialysis-related amyloidosis is a major complication in long-term hemodialysis patients. In dialysis-related amyloidosis, β2-microglobulin (β2-m) amyloid fibrils deposit in the osteoarticular tissue, leading to carpal tunnel syndrome and destructive arthropathy with cystic bone lesions, but the mech...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Okoshi, Tadakazu, Yamaguchi, Itaru, Ozawa, Daisaku, Hasegawa, Kazuhiro, Naiki, Hironobu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589361/
https://ncbi.nlm.nih.gov/pubmed/26421922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139330
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