Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury

Brain edema following traumatic brain injury (TBI) is associated with considerable morbidity and mortality. Prior indirect evidence has suggested the involvement of astrocyte water channel aquaporin-4 (AQP4) in the pathogenesis of TBI. Here, focal TBI was produced in wild type (AQP4(+/+)) and knocko...

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Bibliografiske detaljer
Udgivet i:J Neurotrauma
Main Authors: Yao, Xiaoming, Uchida, Kazuyoshi, Papadopoulos, Marios C., Zador, Zsolt, Manley, Geoffrey T., Verkman, Alan S.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2015
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589265/
https://ncbi.nlm.nih.gov/pubmed/25790314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2014.3675
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