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Localized smooth muscle differentiation is essential for epithelial bifurcation during branching morphogenesis of the mammalian lung

The airway epithelium develops into a treelike structure via branching morphogenesis. Here we show a critical role for localized differentiation of airway smooth muscle during epithelial bifurcation in the embryonic mouse lung. We found that during terminal bifurcation, changes in the geometry of na...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Kim, Hye Young, Pang, Mei-Fong, Varner, Victor D., Kojima, Lisa, Miller, Erin, Radisky, Derek C., Nelson, Celeste M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589145/
https://ncbi.nlm.nih.gov/pubmed/26387457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.08.012
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