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CD73: A potential biomarker for anti-PD-1 therapy
In our recent study, we show that tumoral CD73 expression limits the efficacy of anti-PD-1 therapy, and this is rescued by concomitant A(2A) blockade. Since CD73 is known to be overexpressed in several human cancers and A(2A) antagonists have undergone clinical trials for Parkinson's Disease, t...
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| Publié dans: | Oncoimmunology |
|---|---|
| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4589050/ https://ncbi.nlm.nih.gov/pubmed/26451321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1046675 |
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