N-Farnesyloxy-norcantharimide inhibits progression of human leukemic Jurkat T cells through regulation of mitogen-activated protein kinase and interleukin-2 production

This study investigated the anticancer effects of N-farnesyloxy-norcantharimide (NOC15), a newly synthesized norcantharidin (NCTD) analogue, on human leukemic Jurkat T cells and the signaling pathway underlying its effects. We found that the half maximal inhibitory concentration (IC50) of NOC15 on J...

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Detalles Bibliográficos
Publicado en:Anticancer Drugs
Main Authors: Chang, Ming-Che, Wu, Jin-Yi, Liao, Hui-Fen, Chen, Yu-Jen, Kuo, Cheng-Deng
Formato: Artigo
Idioma:Inglês
Publicado: Lippincott Williams & Wilkins 2015
Assuntos:
Preclinical Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588604/
https://ncbi.nlm.nih.gov/pubmed/26288134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CAD.0000000000000284
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