Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages

MCJ (DNAJC15) is a mitochondrial protein that regulates the mitochondrial metabolic status of macrophages and their response to inflammatory stimuli. CpG island methylation in cancer cells constitutes the only mechanism identified for the regulation of MCJ gene expression. However, whether DNA methy...

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Publicado en:Sci Rep
Autores principales: Navasa, Nicolás, Martin-Ruiz, Itziar, Atondo, Estíbaliz, Sutherland, James D., Angel Pascual-Itoiz, Miguel, Carreras-González, Ana, Izadi, Hooman, Tomás-Cortázar, Julen, Ayaz, Furkan, Martin-Martin, Natalia, Torres, Iviana M, Barrio, Rosa, Carracedo, Arkaitz, Olivera, Elias R., Rincón, Mercedes, Anguita, Juan
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588509/
https://ncbi.nlm.nih.gov/pubmed/26419808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14692
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