Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages

MCJ (DNAJC15) is a mitochondrial protein that regulates the mitochondrial metabolic status of macrophages and their response to inflammatory stimuli. CpG island methylation in cancer cells constitutes the only mechanism identified for the regulation of MCJ gene expression. However, whether DNA methy...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Navasa, Nicolás, Martin-Ruiz, Itziar, Atondo, Estíbaliz, Sutherland, James D., Angel Pascual-Itoiz, Miguel, Carreras-González, Ana, Izadi, Hooman, Tomás-Cortázar, Julen, Ayaz, Furkan, Martin-Martin, Natalia, Torres, Iviana M, Barrio, Rosa, Carracedo, Arkaitz, Olivera, Elias R., Rincón, Mercedes, Anguita, Juan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588509/
https://ncbi.nlm.nih.gov/pubmed/26419808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14692
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