Combined activation of the energy and cellular-defense pathways may explain the potent anti-senescence activity of methylene blue

Methylene blue (MB) delays cellular senescence, induces complex-IV, and activates Keap1/Nrf2; however, the molecular link of these effects to MB is unclear. Since MB is redox-active, we investigated its effect on the NAD/NADH ratio in IMR90 cells. The transient increase in NAD/NADH observed in MB-tr...

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Udgivet i:Redox Biol
Main Authors: Atamna, Hani, Atamna, Wafa, Al-Eyd, Ghaith, Shanower, Gregory, Dhahbi, Joseph M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588422/
https://ncbi.nlm.nih.gov/pubmed/26386875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.09.004
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