Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis

Mitochondrial homeostasis is critical for tissue health, and mitochondrial dysfunction contributes to numerous diseases, including heart failure. Here, we have shown that the transcription factor Kruppel-like factor 4 (KLF4) governs mitochondrial biogenesis, metabolic function, dynamics, and autopha...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Liao, Xudong, Zhang, Rongli, Lu, Yuan, Prosdocimo, Domenick A., Sangwung, Panjamaporn, Zhang, Lilei, Zhou, Guangjin, Anand, Puneet, Lai, Ling, Leone, Teresa C., Fujioka, Hisashi, Ye, Fang, Rosca, Mariana G., Hoppel, Charles L., Schulze, P. Christian, Abel, E. Dale, Stamler, Jonathan S., Kelly, Daniel P., Jain, Mukesh K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588311/
https://ncbi.nlm.nih.gov/pubmed/26241060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79964
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