Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease

Regulatory T cells (Tregs) have been shown to enhance immune reconstitution and prevent graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation; however, it is unclear how Tregs mediate these effects. Here, we developed a model to examine the mechanism of Treg-dependent regula...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Bolton, Holly A., Zhu, Erhua, Terry, Alexandra M., Guy, Thomas V., Koh, Woon-Puay, Tan, Sioh-Yang, Power, Carl A., Bertolino, Patrick, Lahl, Katharina, Sparwasser, Tim, Shklovskaya, Elena, de St. Groth, Barbara Fazekas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588278/
https://ncbi.nlm.nih.gov/pubmed/26301814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76031
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