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Contribution of Epigenetic Modifications to the Decline in Transgene Expression from Plasmid DNA in Mouse Liver

Short-term expression of transgenes is one of the problems frequently associated with non-viral in vivo gene transfer. To obtain experimental evidence for the design of sustainable transgene expression systems, the contribution of epigenetic modifications to the decline in transgene expression needs...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Zang, Lei, Nishikawa, Makiya, Ando, Mitsuru, Takahashi, Yuki, Takakura, Yoshinobu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588195/
https://ncbi.nlm.nih.gov/pubmed/26262639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics7030199
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